Corpus ID: 35541803

The effect of cholinesterase inhibitors on the toxicity of procaine in mice.

@article{Conway1949TheEO,
  title={The effect of cholinesterase inhibitors on the toxicity of procaine in mice.},
  author={Ainslie Conway and Kuang-Sheng. Ting and Julius M. Coon},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1949},
  volume={96 4 Pt. 1},
  pages={
          472-6
        }
}
  • Ainslie Conway, Kuang-Sheng. Ting, Julius M. Coon
  • Published 1949
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1. Four cholinesterase inhibitors and one non-esterase inhibiting parasympatthetic stimulant were tested for their effect on intravenous procaine toxicity in mice premedicated with the drugs. 2. Physostigmine and DFP showed significant protective effects, increasing the LD 50 of procaine 23 and 16 per cent, respectively. 3. Neostigmine and carbamic acid, N,N-dimethyl-4-dimethylamino-3-isopropyiphenyl ester, methiodide increased the susceptibility of mice to the toxic action of intravenous… CONTINUE READING

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