The effect of cholesterol on the reconstitution of alkaline phosphatase into liposomes.

@article{Bolean2010TheEO,
  title={The effect of cholesterol on the reconstitution of alkaline phosphatase into liposomes.},
  author={Mayt{\^e} Bolean and Ana Maria Sper Sim{\~a}o and Bruno Zoccaratto Favarin and J. L. Mill{\'a}n and Pietro Ciancaglini},
  journal={Biophysical chemistry},
  year={2010},
  volume={152 1-3},
  pages={
          74-9
        }
}
Tissue-nonspecific alkaline phosphatase (TNAP), present on the surface of chondrocyte- and osteoblast-derived matrix vesicles (MVs), plays key enzymatic functions during endochondral ossification. Many studies have shown that MVs are enriched in TNAP and also in cholesterol compared to the plasma membrane. Here we have studied the influence of cholesterol on the reconstitution of TNAP into dipalmitoylphosphatidylcholine (DPPC)-liposomes, monitoring the changes in lipid critical transition… CONTINUE READING
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