The effect of cholecystectomy on plasma cholecystokinin

  title={The effect of cholecystectomy on plasma cholecystokinin},
  author={Ciaran McDonnell and Ian Bailey and Thomas Stumpf and Thomas Noel Walsh and Colin David Johnson},
  journal={American Journal of Gastroenterology},
OBJECTIVE:Gallbladder removal is associated with an increased incidence of gastroesophageal reflux, but the mechanism is unclear. Cholecystokinin (CCK) release, which causes gallbladder contraction, is inhibited by bile in the duodenum. This study investigates the effect of cholecystectomy on meal-stimulated CCK secretion.METHODS:Three groups of patients were studied. Group 1 (n = 15) were normal controls. Group 2 (n = 27) were patients with symptomatic gallstones. Group 3 (n = 25) were… CONTINUE READING