The effect of chelator type on in vitro receptor binding and stability in 177Lu-labeled cetuximab and panitumumab.

@article{Nov2014TheEO,
  title={The effect of chelator type on in vitro receptor binding and stability in 177Lu-labeled cetuximab and panitumumab.},
  author={Zbyněk Nov{\'y} and Alice L{\'a}zn{\'i}{\vc}kov{\'a} and Jana Mand{\'i}kov{\'a} and Pavel B{\'a}rta and Milan L{\'a}zn{\'i}{\vc}ek and Franti{\vs}ek Trejtnar},
  journal={Journal of labelled compounds & radiopharmaceuticals},
  year={2014},
  volume={57 7},
  pages={448-52}
}
Monoclonal antibodies are used in the therapy of various diseases. Thanks to their high specific uptake in target tissues, these antibodies can be utilized in targeted radioimmunotherapy as carriers of radioisotopes to tumors. However, important characteristics of antibodies such as target binding and stability in the organism may be affected by various structural parameters. This study has focused on the potential influence of selected chelators on radiochemical quality and in vitro receptor… CONTINUE READING