Corpus ID: 2813664

The effect of ceramide-containing skin care products on eczema resolution duration.

  title={The effect of ceramide-containing skin care products on eczema resolution duration.},
  author={Zoe Diana Draelos},
  volume={81 1},
Eczema is a common dermatologic condition that affects children as well as adults and is related to a defective skin barrier, which is most commonly caused by damage to the intercellular lipids from improper selection of skin cleansers and moisturizers. A new concept in skin care is the incorporation of ceramides into therapeutic cleansers and moisturizers. Ceramides are important components of the intercellular lipids that are necessary to link the protein-rich corneocytes into a waterproof… 
Acceptability and Efficacy of an Emollient Containing Ceramide-Precursor Lipids and Moisturizing Factors for Atopic Dermatitis in Pediatric Patients
It seems that patients who found the LMF moisturizer acceptable were less likely to be female or to be colonized by S. aureus before switching to the product, and they had less severe eczema, less pruritus, and less sleep disturbance after its use than patients who did not find the product acceptable.
Effect of moisturizers on epidermal barrier function.
Moisturizers with barrier-improving properties may delay relapse of dermatitis in patients with atopic dermatitis and other dry skin conditions, and in a worst-case scenario, treatment with moisturizing creams could increase the risks of Dermatitis and asthma.
Moisturizers and Ceramide-containing Moisturizers May Offer Concomitant Therapy with Benefits.
It is proposed that adjunctive therapy with moisturizer, particularly ceramide-containing moisturizers, should be considered in acne-treated patients.
An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
The sustained moisturization imparted by the test products reduces the need for frequent emollient application, often requiring 3–4 applications per day for traditional emollients, and should reduce the high burden of managing dry skin conditions like atopic dermatitis.
Prevention or promotion of dryness and eczema by moisturizers
A defect in skin barrier function has been suggested as the major cause for atopic eczema, and knowledge regarding the mechanisms of the impact of different ingredients on the skin is still lacking.
Barrier Repair Therapy in Atopic Dermatitis: An Overview
Some evidence that certain products had therapeutic efficacy in improving clinical and/or biophysical parameters of patients with AD is found, but study methods were often flawed and sample sizes were small.
Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema.
Patients who accepted the cream had less pruritus and improved quality of life than the non-accepting patients following its usage, and the trial cream was acceptable in three quarters of patients with atopic dermatitis.
Ceramide liposomes for skin barrier recovery: a novel formulation based on natural skin lipids.
Stable liposomal systems containing ceramides and other SC lipids, and the ability of the system to repair chemically-damaged porcine skin was tested, suggesting that the approach to liposome development has considerable potential for the repair of a disrupted skin barrier.
Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review
The clinical effect of moisturizers is well-documented, and urea-based preparations may be preferable as a first-line treatment, but there is an unmet need for well-powered comparisons between individual moisturizers.
Use of Moisturizers in Patients with Atopic Dermatitis
Regular topical application of a moisturizer is the key in the management of patients with AD and a number of studies have been done to demonstrate how the efficacy of moisturizer therapy can be objectively measured.


Influence of topically applied ceramide/phospholipid mixture on the barrier function of intact skin, atopic skin and experimentally induced barrier damage
Stabilizing effects on the barrier function after application of ceramide/phospholipid‐mixture were found only in atopic skin and after lipid extraction but not in healthy skin, and the results lead us to expect positive effects of ceramia/ph phospholipidsmixture only if barrier damage is present.
Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin.
Findings show that barrier recovery is accelerated in chronologically aged murine epidermis with optimized ratios of physiologic lipids, provided that cholesterol is the dominant lipid and that the same mixture also accelerates barrier recovery in chronological aged human skin.
Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment
The ability of the opiimal lipid mixture to accelerate barrier repair after both moderate and extensive degrees of barrier disruption suggests a potential clinical use for this approach.
Selective recovery of deranged water-holding properties by stratum corneum lipids.
The hypothesis that structural lipids present in the intercellular spaces of the stratum corneum, especially ceramide, play a critical role in the water-holding properties of the Stratum Corneum is strengthened.
Repair of acetone‐ and sodium lauryl sulphate‐damaged human skin barrier function using topically applied emulsions containing barrier lipids
This work states that well‐formulated moisturizing skin care products can restore disturbed barrier function that can be assessed by transepidermal water loss measurements, but it is not always clearly demonstrated which ingredients of the formulation exert the beneficial effects.
inventor; HealthPoint, Ltd, assignee. Multivesicular emulsion drug delivery systems. US patent 6,709,663
  • March 23,
  • 2004