The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleukin-1beta response in rats.

@article{Shimizu2004TheEO,
  title={The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleukin-1beta response in rats.},
  author={Hideki Shimizu and Michio Miyoshi and Kenji Matsumoto and Osamu Goto and Toshiaki Imoto and Tatsuo Watanabe},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 3},
  pages={865-73}
}
We recently reported an involvement of peripheral angiotensin II (ANG II) in the development of both the fever and the peripheral interleukin (IL)-1beta production induced in rats by a systemic injection of lipopolysaccharide (LPS). The present study was performed to investigate whether brain ANG II contributes to the fever and IL-1beta production in the rat brain induced by i.c.v. injection of LPS. LPS (0.2 and 2 microg i.c.v.) induced dose-related fevers and increases in the brain… CONTINUE READING