The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat.

Abstract

Neuropeptide Y (NPY) and the endogenous kappa-opioid receptor ligand, dynorphin (dyn), stimulate feeding when injected centrally in the rat. Norbinaltorphimine (norBNI, 25 nmol) reduced the feeding response to NPY (2.4 nmol) by 67% (P < 0.02). An additive effect of dynorphin and NPY was seen on food intake (saline 0.8 +/- 0.1, dyn 1.9 +/- 0.4, NPY 6.1 +/- 1.4, dyn and NPY 9.7 +/- 2.2). A component of NPY-induced feeding may be mediated by kappa-opioid neuronal systems.

Cite this paper

@article{Lambert1993TheEO, title={The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat.}, author={Philip D. Lambert and John P H Wilding and A A al-Dokhayel and Stephen George Gilbey and Stephen R. Bloom}, journal={Brain research}, year={1993}, volume={629 1}, pages={146-8} }