The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine

@inproceedings{SabouriRad2017TheEO,
  title={The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine},
  author={Sarvenaz Sabouri-Rad and R K Oskuee and Asma Mahmoodi and Leila Gholami and Bizhan Malaekeh-Nikouei},
  booktitle={BioImpacts : BI},
  year={2017}
}
Introduction: Cationic polymers have the potential to be modified to achieve an ideal gene vector lacking viral vector defects. The aim of the present study was to improve polyallylamine (PAA) transfection efficiency and to reduce cytotoxicity by incorporating of cell-penetrating peptides (CPPs). Methods: To prepare the peptide-based polyplexes, PAA (15 kDa) was modified with 2 peptides (TAT and CyLoP-1) by covering the 0.5% and 1% of amines. Buffer capacity and DNA condensation ability of… CONTINUE READING

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SHOWING 1-10 OF 39 REFERENCES

Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2016
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Intracellular delivery of nanoparticles via the HIV - 1 tat peptide

C Berry
  • Nanomedicine ( Lond )
  • 2008

Intracellular delivery of nanoparticles via the HIV-1 tat peptide. Nanomedicine (Lond)

C. Berry
  • 2008