The effect of cell killing by x-irradiation on pattern formation in the chick limb.

@article{Wolpert1979TheEO,
  title={The effect of cell killing by x-irradiation on pattern formation in the chick limb.},
  author={Robert L. Wolpert and Cheryll Tickle and M Sampford},
  journal={Journal of embryology and experimental morphology},
  year={1979},
  volume={50},
  pages={
          175-93
        }
}
It has been suggested that positional information along the proximo-distal axis of the limb-bud is specified by time spent in the progress zone. Mesenchyme cells have been killed by X-irradiation, reducing the rate cells leave the zone. The time spent there by some cells is thus increased. When limbs, stage 18/19, stage 21, or tips of stage 24, are treated with increasing doses of X-irradiation, from 1000 rads to 2500 rads proximal structures are progressively lost, whereas distal ones--the… CONTINUE READING

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