The effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicals.

  title={The effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicals.},
  author={T. Habon and E. Szabados and G. K{\'e}sm{\'a}rky and R. Halmosi and T. Past and B. Sumegi and K. Toth},
  journal={Cardiovascular research},
  volume={52 1},
  • T. Habon, E. Szabados, +4 authors K. Toth
  • Published 2001
  • Chemistry, Medicine
  • Cardiovascular research
  • OBJECTIVE Previous studies have reported that the beta and alpha adrenoceptor blocker carvedilol has unique protective effects on free radical-induced myocardial injury. The aim of this study was to examine how carvedilol regulates reactive-oxygen-species-mediated signaling and decreases red blood cell membrane damage in heart perfusion and in a rheological model. METHODS The ischemia-reperfusion-induced oxidative cell damage, and changes in the intracellular signaling mediated by reactive… CONTINUE READING
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