The effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicals.

@article{Habon2001TheEO,
  title={The effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicals.},
  author={T. Habon and E. Szabados and G. K{\'e}sm{\'a}rky and R. Halmosi and T. Past and B. Sumegi and K. Toth},
  journal={Cardiovascular research},
  year={2001},
  volume={52 1},
  pages={
          153-60
        }
}
  • T. Habon, E. Szabados, +4 authors K. Toth
  • Published 2001
  • Chemistry, Medicine
  • Cardiovascular research
    • OBJECTIVE Previous studies have reported that the beta and alpha adrenoceptor blocker carvedilol has unique protective effects on free radical-induced myocardial injury. The aim of this study was to examine how carvedilol regulates reactive-oxygen-species-mediated signaling and decreases red blood cell membrane damage in heart perfusion and in a rheological model. METHODS The ischemia-reperfusion-induced oxidative cell damage, and changes in the intracellular signaling mediated by reactive… CONTINUE READING
    View on PubMed
    academic.oup.com
    23 Citations
    Highly Influencial Citations
    1
    Background Citations
    10
    Methods Citations
    2
    23 Citations
    Citation Type

    Citation Type

    Influence of carvedilol on superoxide generation and enzyme release from stimulated human neutrophils.
    • 6
    • PDF
    Scavenger Effect of Experimental and Clinically Used Cardiovascular Drugs
    • 29
    Inhibition of chemiluminescence by carvedilol in the cell‐free system, whole human blood and blood cells
    • 9
    2,2,5,5-Tetramethylpyrroline-Based Compounds in Prevention of Oxyradical-induced Myocardial Damage
    • 14
    Effects of carvedilol on cardiomyocyte apoptosis and gene expressionin vivo after ischemia-reperfusion in rats
    • 13
    Prevention of Doxorubicin-Induced Acute Cardiotoxicity by an Experimental Antioxidant Compound
    • 58
    Hemorheological methods in drug research.
    • 4
    Neutrophils superoxide anion generation during carvedilol therapy in patients with stable angina.
    • 2
    Cellular and molecular mechanisms of the enhanced survival benefits of the β I -adrenoceptor biased agonist, carvedilol, in diabetic cardiomyopathy with heart failure: a case report and literature review
    • Highly Influenced
    Effects of Administered Cardioprotective Drugs on Treatment Response of Breast Cancer Cells.
    • 12

    References

    SHOWING 1-10 OF 96 REFERENCES
    Carvedilol, a new vasodilating beta adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils.
    • 65
    In vitro method for measurement of free radical effects: effect of PMS (phenazine methosulphate) on red blood cell membrane.
    • 4
    Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate.
    • 45
    Malondialdehyde and glutathione production in isolated perfused human and rat hearts.
    • 35
    • PDF
    Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
    • 136
    Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart.
    • 116
    Activated granulocyte induced alterations in red blood cells and protection by antioxidant enzymes
    • 32
    The interaction of acteoside with mitochondrial lipid peroxidation as an ischemia/reperfusion injury model.
    • N. Pan, H. Hori
    • Chemistry, Medicine
    • Advances in experimental medicine and biology
    • 1994
    • 16
    The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.
    • 35
    Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
    • 301
    • PDF