The effect of cantharidins on leukemic stem cells

@article{Dorn2009TheEO,
  title={The effect of cantharidins on leukemic stem cells},
  author={David C. Dorn and Cynthia A. Kou and Kim J. Png and M. Moore},
  journal={International Journal of Cancer},
  year={2009},
  volume={124}
}
To identify an agent with specific activity against leukemic stem cells (LSCs), we evaluated compounds that targeted hepatic leukemia factor (HLF), a gene implicated in hematopoietic stem cell (HSCs) regulation, that we found overexpressed in LSCs. [...] Key Result Cantharidin and norcantharidin, a derivative with reduced toxicity, decreased HLF protein levels and induced apoptosis in the AML cell line MV4-11 by modulating the expression of several molecules that govern survival pathway, including HLF, SLUG…Expand
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