The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat

@article{Rock2007TheEO,
  title={The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat},
  author={Erin M Rock and Cheryl L. Limebeer and Raphael Mechoulam and Daniele Piomelli and Linda A Parker},
  journal={Psychopharmacology},
  year={2007},
  volume={196},
  pages={389-395}
}
Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. The potential of cannabidiol (CBD) and the fatty acid amide hydrolase (FAAH) inhibitor, URB597 (URB) to reduce conditioned gaping in rats were evaluated. In each experiment, rats received four conditioning trials in which they were injected with… CONTINUE READING

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Exposure to a context previously associated with toxin (LiCl)-or motion-induced sickness elicits conditioned

CL Limebeer, JP Krohn, +3 authors LA Parker
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