The effect of calcium on potassium‐induced depolarization of adrenal glomerulosa cells

  title={The effect of calcium on potassium‐induced depolarization of adrenal glomerulosa cells},
  author={Richard H. Foster and Maria V.T. Lobo and Howard Rasmussen and Elisa T. Marusic},
  journal={FEBS Letters},

Participation of voltage-dependent calcium channels in the regulation of adrenal glomerulosa function by angiotensin II and potassium.

A major and selective role of voltage-dependent calcium channels in the control of aldosterone secretion by the major physiological regulators, AII and potassium is shown.

Signal Transduction and Ion Permeability in Adrenal Glomerulosa Cells

Different transduction mechanisms have been proposed in relation to the effects of these factors and include cAMP formation, regulation of cytosolic free calcium through the phosphatidylinositol system, and ion channel modification, protein kinase C activation, and modification of the membrane potential.

Effect of angiotensin II, ATP, and ionophore A23187 on potassium efflux in adrenal glomerulosa cells.

The results suggest that Ca-dependent K channels or carriers are present in the membranes of bovine adrenal glomerulosa cells and are sensitive to hormonal stimulus.

The mechanism of the effect of K+ on the steroidogenesis of rat zona glomerulosa cells of the adrenal cortex: role of cyclic AMP

  • P. HyattJ. TaitS. Tait
  • Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1986
It is concluded that in the physiological range of K+ concentrations, the role of cAMP in zona glomerulosa cells is at least comparable in importance to that of non-cAMP mechanisms.

External calcium is required for activation of phospholipase C by angiotensin II in adrenal glomerulosa cells

The requirement for Ca2+ during AII-induced activation of phospholipase C may be explained, at least partly, by a requirement forCa2+ at a site between the AII receptor and Phospholipases C.

Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis.

According to these experiments, calcium is an important second messenger mediating the effects of a high extra-cellular potassium concentration on the expression of genes encoding steroidogenic enzymes in rat zona glomerulosa cells.

Effects of ANG II and K+ on Ca efflux and aldosterone production in adrenal glomerulosa cells.

A comparison was made of the effects of angiotensin II (ANG II) and K+ on aldosterone secretion and calcium efflux from porcine adrenal glomerulosa cells and dantrolene greatly inhibited ANG II-induced increase in the fractional efflux ratio of calcium.

Reciprocal influences between the signalling pathways regulating proliferation and steroidogenesis in adrenal glomerulosa cells.

  • R. Foster
  • Biology, Medicine
    Journal of molecular endocrinology
  • 2004
Experimental evidence of possible reciprocal influences between the signalling pathways regulating proliferation and steroidogenesis in ZG cells is discussed.

Effects of dihydropyridines on aldosterone secretion in adrenal capsule preparations from pregnant rats.

The results indicate that voltage-operated calcium channels involved in aldosterone secretion are functionally impaired during pregnancy.



Membrane potential changes of mouse adrenal zona fasciculata cells in response to adrenocorticotropin and adenosine 3',5'-monophosphate.

It is indicated that ACTH initiates a complex series of events by which steroidogenesis is stimulated, which may involve a change in membrane permeability to Ca++ independently of cAMP generation; a second mechanism may involve the activation of adenylate cyclase which subsequently influences the membrane conductance of the fasciculata cell membrane.

Dependence of aldosterone stimulation in adrenal glomerulosa cells on calcium uptake: effects of lanthanum nd verapamil.

Results provide further evidence that angiotensin II and potassium increase aldosterone production in adrenal glomerulosa cells through a calcium-dependent mechanism, and indicate that calcium uptake is an essential requirement for the stimulation of ald testosterone production by these two effectors.

Calcium: its role in the mechanism of action of angiotensin II and potassium in aldosterone production.

It is concluded that angiotensin II and potassium activate the cells of the glomerulosa by increasing the entry of calcium into the cell, which serves an important messenger function in the response of this cell to ang Elliotensin I and potassium.

Further studies on the relationship between potassium and sodium levels and adrenocortical activity.

The dissociation observed between intracellular potassium levels and aldosterone production suggests that there is not a simple relationship between the two parameters, and changes in external potassium and sodium levels modulate ald testosterone as well as corticosterone, but not cortisol production.

Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation.

  • H. KorchakG. Weissmann
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1978
The data suggest that DeltaPsi is involved in primary triggering of phagocytic cells and that metabolic stimulation is a secondary consequence of ligand-receptor interactions.

Use of a lipophilic cation for determination of membrane potential in neuroblastoma-glioma hybrid cell suspensions.

TPP(+) distribution measurements can provide a biochemical method for determining membrane potentials in populations of cultured neuronal cells and are corroborated by intracellular recording techniques.

Mechanics and energetics of lengthening of active airway smooth muscle.

It was shown that the net rate of energy liberation in an elongating active muscle is less than that of a muscle contracting isometrically, and it may be speculated that distension of the airway during inspiration would not be associated with mechanical instability.