The effect of caffeine upon cell survival and post-replication repair of DNA after treatment of BHK 21 cells with either UV irradiation or N-methyl-n-nitrosoguanidine.

@article{Gascoigne1981TheEO,
  title={The effect of caffeine upon cell survival and post-replication repair of DNA after treatment of BHK 21 cells with either UV irradiation or N-methyl-n-nitrosoguanidine.},
  author={E W Gascoigne and A C Robinson and William J. Harris},
  journal={Chemico-biological interactions},
  year={1981},
  volume={36 1},
  pages={107-16}
}
It has been found that in BHK 21 cells caffeine potentiates cell killing by both UV irradiation and N-methyl-N-nitrosoguanidine (MNNG). The potentiating effect is greater with UV than with MNNG. While non-toxic concentrations of caffeine inhibit the joining of newly-replicated DNA fragments into large molecular weight DNA (post-replication repair) after UV irradiation, they have no such effect after MNNG treatment. Furthermore, the joining of DNA fragments continues in the cells treated with 3… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…