The effect of caffeine on intraocular pressure: a systematic review and meta-analysis

  title={The effect of caffeine on intraocular pressure: a systematic review and meta-analysis},
  author={Mao Li and Min Wang and Wen-yi Guo and Jiajian Wang and Xinghuai Sun},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  • Mao Li, Min Wang, Xinghuai Sun
  • Published 1 March 2011
  • Medicine
  • Graefe's Archive for Clinical and Experimental Ophthalmology
BackgroundCaffeine is widely consumed, and its effect on intraocular pressure (IOP) has been reported in conflicting data. The aim of this meta-analysis was to quantitatively summarize the effect of caffeine on IOP in normal individuals and in patients with glaucoma or ocular hypertension (OHT).MethodsA comprehensive literature search was performed using the Cochrane Collaboration methodology to identify pertinent randomized controlled trials (RCTs) from the Cochrane Central Register of… 
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Reductions in Intraocular Pressure After Acute Aerobic Exercise: A Meta-Analysis
There is a robust effect of exercise on IOP for sedentary participants, however, the heterogeneity across study parameters, such as exercise protocol, IOP measurement, and participant selection, prohibited the inclusion of studies in this analysis that may have influenced the results.
Assessment of the Effect of Caffeine on Intraocular Pressure Among Adults Attending the Ophthalmic Clinics of Irrua Specialist Teaching Hospital
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Effects of caffeine on intraocular pressure are subject to tolerance: a comparative study between low and high caffeine consumers
The results of this placebo-controlled, double-blind, and balanced crossover study suggest that IOP responsiveness to caffeine ingestion is subject to tolerance, which could have important implication in the management of glaucoma.
Acute effects of caffeine on choroidal thickness and ocular pulse amplitude
A prospective observational study to explore ocular changes in healthy people after caffeine consumption found no significant change in IOP and OPA following oral 200 mg caffeine intake, while CT significantly decreased, for at least 4 h.
Modifiable factors in the management of glaucoma: a systematic review of current evidence
Certain lifestyle habits could influence glaucoma progression, yet no specific interventions are currently supported by robust evidence, yet awareness of the possible influences of certain habits should help guide clinical advice.
Dietary factors and the risk of glaucoma: a review
Initial reports in the literature suggest a potential role for dietary modification in the treatment of glaucomatous optic neuropathy with possible relationship indicating increased risk of the disease with increased consumption of these dietary factors.


The effect of caffeine on intraocular pressure in glaucoma patients.
There was a statistically significant difference in the change in IOP at 90 minutes when comparing coffee to tea (P = 0.003) and no significant difference for 30 and 60 minutes; however, the change was not clinically significant.
Effect of Coffee Consumption on Intraocular Pressure
Subjects who drank regular coffee demonstrated a greater elevation in intraocular pressure after ingestion of regular versus decaffeinated coffee; this elevation may be clinically significant.
Effects of Caffeine on Intraocular Pressure: The Blue Mountains Eye Study
In participants with open-angle glaucoma, this study identified a positive cross-sectional association between coffee consumption/higher caffeine intakes and elevated intraocular pressure.
The Effect of Caffeine on Retrobulbar Hemodynamics
The vascular resistance of the retrobulbar vessels appears to be altered by caffeine consumption, and further studies are needed to investigate the effects of caffeine on hemodynamics in patients with glaucoma.
Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis.
The prevalence of OAG was one third lower in studies in which routine visual fields were not assessed and that used an IOP criterion in the definition of glaucoma; this effect was reduced to the null after adjustment for age, racial group, and year of publication.
The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals.
Topical ocular hypotensive therapy is effective in delaying or preventing the onset of POAG in African American individuals who have ocular hypertension.
Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial.
Patients treated in the EMGT had half of the progression risk of control patients, including the effect of EMGT treatment, and the magnitude of initial IOP reduction was a major factor influencing outcome.