The effect of cadmium on Aβ levels in APP/PS1 transgenic mice.

@article{Li2012TheEO,
  title={The effect of cadmium on Aβ levels in APP/PS1 transgenic mice.},
  author={Xiaoling Li and Yongli Lv and Song Yu and Haihua Zhao and Lijie Yao},
  journal={Experimental and therapeutic medicine},
  year={2012},
  volume={4 1},
  pages={125-130}
}
Cadmium (Cd), which is a poisonous trace element, has been reported extensively to lead to morphological and biochemical abnormalities of the central nervous system, memory loss and mental retardation. We studied the Alzheimer's disease-related toxicity of Cd in a mouse model [amyloid precursor protein (APP)/ presenilin 1 (PS1) transgenic mice, dual transfection of APP695swe and mutated PS1 genes]. Behavioral changes were detected using the Morris water maze test. The β-amyloid protein (A… CONTINUE READING