The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity

@article{Hassan2000TheEO,
  title={The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity},
  author={Moustapha Hassan and Per Ljungman and Olle Ringd{\'e}n and Zuzana Hassan and Gunnar {\"O}berg and Caroline Nilsson and A N B{\'e}k{\'a}ssy and M Bielenstein and Mohamed Abdel-Rehim and Susanna Kumlien Geor{\'e}n and Leonhard Astner},
  journal={Bone Marrow Transplantation},
  year={2000},
  volume={25},
  pages={915-924}
}
Busulphan and cyclophosphamide (Bu/CP) are widely used in preparative regimens for bone marrow transplantation. Many studies have shown a wide variation in busulphan pharmacokinetics. Moreover, higher rates of liver toxicity were reported in Bu/CP protocols than in a total body irradiation (TBI)-containing regimen. In the present paper we investigated the effect of the time interval between the last dose of busulphan and the first dose of cyclophosphamide on the pharmacokinetics of CP and its… CONTINUE READING