The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes

@article{Sayer2005TheEO,
  title={The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes},
  author={Andrew Sayer and Qing Tao Hu and Andrea J. Bourdelais and Daniel G. Baden and James E. Gibson},
  journal={Archives of Toxicology},
  year={2005},
  volume={79},
  pages={683-688}
}
Brevenal is a nontoxic short-chain trans-syn polyether that competes with brevetoxin (PbTx) for the active site on voltage-sensitive sodium channels. The PbTxs are highly potent polyether toxins produced during blooms of several species of marine dinoflagellates, most notably Karenia brevis. Blooms of K. brevis have been associated with massive fish kills, marine mammal poisoning, and are potentially responsible for adverse human health effects such as respiratory irritation and airway… CONTINUE READING