The effect of bone morphogenetic protein-7 (OP-1) and demineralized bone matrix (DBM) in the rabbit tibial distraction model.

@article{Lammens2009TheEO,
  title={The effect of bone morphogenetic protein-7 (OP-1) and demineralized bone matrix (DBM) in the rabbit tibial distraction model.},
  author={J. M. G. Lammens and Jos Nijs and Evert Schepers and Nadine L E Y Ectors and Daniel Lismont and Bert Verduyckt},
  journal={Acta orthopaedica Belgica},
  year={2009},
  volume={75 1},
  pages={103-9}
}
OP-1 (800 microg) or DBM (1900 mg) were implanted in a rabbit tibial distraction model, and healing was compared to a non treated control group. The limbs were harvested after ten weeks and examined using radiography, computerized axial tomography and histological analysis. Neither of the treatments showed a changed healing pattern. Densities as measured by CT scan were not increased and the only significant finding was an increased area of bone formation in the DBM treated group (65% increase… CONTINUE READING

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