The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone.

@article{Pountos2010TheEO,
  title={The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone.},
  author={Ippokratis Pountos and Theodora Georgouli and Karen T Henshaw and Howard Bird and Elena Jones and Peter V Giannoudis},
  journal={Journal of orthopaedic trauma},
  year={2010},
  volume={24 9},
  pages={552-6}
}
INTRODUCTION It has been previously shown that in patients with osteoporosis, mesenchymal stem cell (MSC) growth rate and osteogenic potential is decreased contributing to inferior fracture consolidation. The aim of this study was to investigate the effect of bone morphogenetic protein-2 (BMP-2), BMP-7, parathyroid hormone (PTH), and platelet-derived growth factor (PDGF) on proliferation and osteogenic differentiation of MSCs derived from patients with osteoporosis. MATERIALS AND METHODS… CONTINUE READING

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Trabecular bone was obtained from 10 patients ( four males , mean age 76 years ) with lower extremity osteoporotic fractures .
Trabecular bone was obtained from 10 patients ( four males , mean age 76 years ) with lower extremity osteoporotic fractures .
BMP-7 , BMP-2 , PTH , and PDGF - BB were observed to have a positive effect on osteogenic differentiation of MSCs . BMP-7 and PDGF - BB ( in high doses )
BMP-7 , BMP-2 , PTH , and PDGF - BB were observed to have a positive effect on osteogenic differentiation of MSCs . BMP-7 and PDGF - BB ( in high doses )
Platelet-Derived Growth FactorIs biochemical function of gene productBecaplermin
BMP-7 , BMP-2 , PTH , and PDGF - BB were observed to have a positive effect on osteogenic differentiation of MSCs . BMP-7 and PDGF - BB ( in high doses )
BMP-7 , BMP-2 , PTH , and PDGF - BB were observed to have a positive effect on osteogenic differentiation of MSCs . BMP-7 and PDGF - BB ( in high doses )
Trabecular bone was obtained from 10 patients ( four males , mean age 76 years ) with lower extremity osteoporotic fractures .
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