The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes.

@article{Parish1993TheEO,
  title={The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes.},
  author={Nicole M. Parish and Phillip Chandler and Ruby Quartey-Papafio and E Hatheway Simpson and Anne Cooke},
  journal={European journal of immunology},
  year={1993},
  volume={23 10},
  pages={
          2667-75
        }
}
The non-obese diabetic (NOD) mouse is an established animal model of the autoimmune disease, insulin-dependent diabetes mellitus (IDDM). The NOD-E mouse is a transgenic mouse which expresses the I-E molecule (absent in NOD mice). Expression of I-E protects these mice from both insulitis and IDDM. We have investigated the possible mechanisms of this protection by constructing bone marrow, and combined bone marrow and thymus chimeras between NOD and NOD-E mice. Our data suggest that thymic… CONTINUE READING

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