The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study.

@article{Faxon2002TheEO,
  title={The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study.},
  author={David P. Faxon and Raymond J. Gibbons and Nicolas A. F. Chronos and Paul A Gurbel and Florence H. Sheehan},
  journal={Journal of the American College of Cardiology},
  year={2002},
  volume={40 7},
  pages={
          1199-204
        }
}
OBJECTIVE The purpose of this study was to determine whether Hu23F2G (LeukoArrest), an antibody to the CD11/CD18 integrin receptors, would reduce infarct size in patients undergoing primary angioplasty for an acute myocardial infarction. BACKGROUND Reperfusion injury in acute myocardial infarction has been shown experimentally to be related to neutrophil accumulation. Inhibitors of the CD11/CD18 or CD18 integrin receptors have been shown to reduce infarct size in experimental models… CONTINUE READING
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