The effect of block copolymer structure on the internalization of polymeric micelles by human breast cancer cells.

@article{Mahmud2005TheEO,
  title={The effect of block copolymer structure on the internalization of polymeric micelles by human breast cancer cells.},
  author={A A Hassan Mahmud and Afsaneh Lavasanifar},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2005},
  volume={45 2},
  pages={82-9}
}
The objective of this study was to assess the effect of hydrophilic/hydrophobic block chain lengths on the internalization of poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) micelles by cancer cells. PEO-b-PCL block copolymers with varied PEO and PCL chain lengths were synthesized, assembled to polymeric micelles and loaded with a hydrophobic fluorescent probe (DiI) through a co-solvent evaporation method of physical encapsulation. The slow release of the fluorescent probe… CONTINUE READING

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