The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction.

@article{Serpooshan2013TheEO,
  title={The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction.},
  author={Vahid Serpooshan and Mingming Zhao and Scott A Metzler and Ke Qiang Wei and Parisha B Shah and Andrew Wang and Morteza Mahmoudi and Andrey V. Malkovskiy and Jayakumar Rajadas and Manish J Butte and Daniel Bernstein and Pilar Ruiz-Lozano},
  journal={Biomaterials},
  year={2013},
  volume={34 36},
  pages={9048-55}
}
Regeneration of the damaged myocardium is one of the most challenging fronts in the field of tissue engineering due to the limited capacity of adult heart tissue to heal and to the mechanical and structural constraints of the cardiac tissue. In this study we demonstrate that an engineered acellular scaffold comprising type I collagen, endowed with specific physiomechanical properties, improves cardiac function when used as a cardiac patch following myocardial infarction. Patches were grafted… CONTINUE READING