The effect of beta-blockers on mortality in heart failure with preserved ejection fraction: A meta-analysis of observational cohort and randomized controlled studies.

@article{Fukuta2017TheEO,
  title={The effect of beta-blockers on mortality in heart failure with preserved ejection fraction: A meta-analysis of observational cohort and randomized controlled studies.},
  author={Hidekatsu Fukuta and Toshihiko Goto and Kazuaki Wakami and Nobuyuki Ohte},
  journal={International journal of cardiology},
  year={2017},
  volume={228},
  pages={4-10}
}
BACKGROUND Nearly half of patients with heart failure (HF) have preserved ejection fraction (EF) and the mortality of patients with HF with preserved EF (HFpEF) is high. However, there is no therapy to improve survival in HFpEF. Although observational cohort studies (OCSs) have examined the survival benefit of beta-blockers in HFpEF, the results are inconsistent due to limited power with small sample sizes and/or lack of adjustment for known confounders. Furthermore, recent randomized… CONTINUE READING
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