The effect of beta-adrenergic agonists on the membrane potential of fat-cell mitochondria in situ.

@article{Davis1982TheEO,
  title={The effect of beta-adrenergic agonists on the membrane potential of fat-cell mitochondria in situ.},
  author={Richard J Davis and Billy R. Martin},
  journal={The Biochemical journal},
  year={1982},
  volume={206 3},
  pages={611-8}
}
1. The accumulation of [3H]methyltriphenylphosphonium by isolated fat-cells was used to estimate the membrane potential of mitochondria in situ. 2. Adrenaline caused a large decrease in the accumulation of [3H]methyltriphenylphosphonium. Mitochondria in fat-cells incubated in the presence of adrenaline had a very low calculated membrane potential. This effect was also given by isoprenaline (a beta-adrenergic agonist) and was blocked by propranolol (a beta-adrenergic antagonist). 3. The effect… CONTINUE READING