The effect of benzodiazepines and flumazenil on motor cortical excitability in the human brain

@article{Palmieri1999TheEO,
  title={The effect of benzodiazepines and flumazenil on motor cortical excitability in the human brain},
  author={Maria Giuseppina Palmieri and Cesare Iani and Anna Scalise and Maria Teresa Desiato and Maria Donatella Caramia},
  journal={Brain Research},
  year={1999},
  volume={815},
  pages={192-199}
}
In the present study, the effects of benzodiazepines (diazepam) were evaluated in terms of cortical excitability changes, as tested with transcranial magnetic simulation (TMS). In particular, analyzed were drug-induced changes regarding two selected parameters of TMS: (1) the cortical excitability threshold and (2) the silent period duration (SP). For this purpose, we evaluated the effects of long-term therapy with diazepam in the patients affected by anxiety disorders and the changes induced… CONTINUE READING

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