The effect of basic and acidic fibroblast growth factors (bFGF and aFGF) on the growth of leukemic blast progenitors in acute myelogenous leukemia.

@article{Nara1995TheEO,
  title={The effect of basic and acidic fibroblast growth factors (bFGF and aFGF) on the growth of leukemic blast progenitors in acute myelogenous leukemia.},
  author={Nobuo Nara and Hitoshi Kurokawa and Shuji Tohda and Junji Tomiyama and Kaoru Nagata and Satoshi Tanikawa},
  journal={Experimental hematology},
  year={1995},
  volume={23 9},
  pages={1030-4}
}
The effect of basic and acidic fibroblast growth factors on leukemic blast progenitors was studied in 14 patients with acute myelogenous leukemia and in one patient with chronic myelocytic leukemia in myeloid crisis. bFGF and aFGF stimulated blast-colony formation by leukemic blast progenitors cultured in methylcellulose in two patients. In the other 13 patients, no significant effect of either FGF on blast-colony formation was noted. The combination of bFGF or a FGF and G-CSF, GM-CSF… CONTINUE READING