The effect of attachment site mutations on strand exchange in bacteriophage lambda site-specific recombination.

Abstract

Recombination of phage lambda attachment sites occurs by sequential exchange of the DNA strands at two specific locations. The first exchange produces a Holliday structure, and the second resolves it to recombinant products. Heterology for base substitution mutations in the region between the two strand exchange points (the overlap region) reduces… (More)

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