The effect of aprotinin on hypoxia-reoxygenation-induced changes in neutrophil and endothelial function.

@article{Harmon2004TheEO,
  title={The effect of aprotinin on hypoxia-reoxygenation-induced changes in neutrophil and endothelial function.},
  author={Dominic Colman Harmon and Wei Lan and George Shorten},
  journal={European journal of anaesthesiology},
  year={2004},
  volume={21 12},
  pages={973-9}
}
BACKGROUND AND OBJECTIVE An acute inflammatory response associated with cerebral ischaemia-reperfusion contributes to the development of brain injury. Aprotinin has potential, though unexplained, neuroprotective effects in patients undergoing cardiac surgery. METHODS Human neutrophil CD11 b/CD18, endothelial cell intercellular adhesion molecule-1 (ICAM-1) expression and endothelial interleukin (IL)-1beta supernatant concentrations in response to in vitro hypoxia-reoxygenation was studied in… CONTINUE READING