The effect of antiplatelet autoantibodies on megakaryocytopoiesis.

  title={The effect of antiplatelet autoantibodies on megakaryocytopoiesis.},
  author={Robert McMillan and Diane Nugent},
  journal={International journal of hematology},
  volume={81 2},
Immune thrombocytopenic purpura (ITP) is a disorder manifested by isolated thrombocytopenia. In vivo infusion studies in the 1950s and 1960s provided evidence that the thrombocytopenia was due to autoantibody-induced platelet destruction. However, there is mounting evidence that platelet production in this disorder may also be suppressed by antibodies. Early morphologic studies showed megakaryocytic damage in ITP, and these results have been confirmed by ultrastructural studies. Autologous… CONTINUE READING