The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity.

@article{Campo1992TheEO,
  title={The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity.},
  author={Mar{\'i}a Luisa Campo and Kathleen W. Kinnally and Henry Tedeschi},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 12},
  pages={8123-7}
}
In a patch-clamp study, we found antimycin A in low (1-2) microM concentrations decreased the open probability of the multiple conductance channel activity and the approximately 110 picosiemens channel of the inner mitochondrial membrane (for a review of mitochondrial channels see Kinnally, K. W., Antonenko, Yu. N., and Zorov, D. B. (1992) J. Bioenerg. Biomembr. 24, 99-110). Higher antimycin A concentrations (e.g. 10 microM) facilitated multiple conductance channel opening. These effects were… CONTINUE READING

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