Corpus ID: 11721711

The effect of antihistaminic drugs upon the performance of trained rats.

@article{Winter1951TheEO,
  title={The effect of antihistaminic drugs upon the performance of trained rats.},
  author={C. Winter and L. Flataker},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1951},
  volume={101 2},
  pages={
          156-62
        }
}
  • C. Winter, L. Flataker
  • Published 1951
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Rats were trained to climb a vertical rope. The time required for climbing was noted, as well as the behavior of the animals. In general, antihistaminic drugs produced muscular incoordination and evidences of cerebral depression in the trained animals, resulting in prolongation of the climbing time, or even complete failure. Curare also prolonged the climbing time, but the effect appeared to be due to muscular weakness and fatigue, in contrast to the confusion and incoordination observed in the… Expand
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