The effect of antihistamines on the immediate allergic response: a comparative review.

@article{Naclerio1993TheEO,
  title={The effect of antihistamines on the immediate allergic response: a comparative review.},
  author={Robert M. Naclerio},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={1993},
  volume={108 6},
  pages={723-30}
}
Antihistamines are believed to reduce the sneezing and rhinorrhea associated with allergic rhinitis, primarily by competitive antagonism of histamine for H1 cellular receptors, but additional mechanisms of action may contribute to their clinical efficacy. To improve our understanding of H1 antihistamine action, we studied the effects of pretreatment with terfenadine, cetirizine, ketotifen, azatadine, diphenhydramine, and azelastine on increases in vascular permeability, mast cell activation… CONTINUE READING