The effect of antidrug antibodies on the sustainable efficacy of biologic therapies in rheumatoid arthritis: practical consequences.

@article{Keiserman2014TheEO,
  title={The effect of antidrug antibodies on the sustainable efficacy of biologic therapies in rheumatoid arthritis: practical consequences.},
  author={Mauro Waldemar Keiserman and Cătălin Codreanu and Rohini Handa and Daniel X Xibill{\'e}-Friedmann and Eduardo F Mysler and Francisco Brice{\~n}o and Servet Akar},
  journal={Expert review of clinical immunology},
  year={2014},
  volume={10 8},
  pages={1049-57}
}
Biologic therapies, predominantly TNF-α inhibitors, have revolutionized the treatment of rheumatoid arthritis (RA). However, their clinical utility can be limited by the development of antidrug antibodies (ADAs). Immunogenicity is a complex phenomenon related to various drug, disease, and patient characteristics, and may be more common with the monoclonal antibodies than with etanercept, a soluble TNF receptor-Fc immunoglobulin fusion protein. Neutralizing antibodies - those that hinder… CONTINUE READING
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