The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple-strain pathogens.

@article{Ferguson1999TheEO,
  title={The effect of antibody-dependent enhancement on the transmission dynamics and persistence of multiple-strain pathogens.},
  author={Neil M. Ferguson and Roy M. Anderson and Sunetra Gupta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 2},
  pages={
          790-4
        }
}
Cross-reactive antibodies produced by a mammalian host during infection by a particular microparasitic strain usually have the effect of reducing the probability of the host being infected by a different, but closely related, pathogen strain. Such cross-reactive immunological responses thereby induce between-strain competition within the pathogen population. However, in some cases such as dengue virus, evidence suggests that cross-reactive antibodies act to enhance rather than restrict the… CONTINUE READING

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