The effect of anti-L-selectin (aselizumab) in multiple traumatized patients—Results of a phase II clinical trial*

@article{Seekamp2004TheEO,
  title={The effect of anti-L-selectin (aselizumab) in multiple traumatized patients—Results of a phase II clinical trial*},
  author={Andreas Seekamp and Martijn van Griensven and Erwin Dhondt and Michael Diefenbeck and Ignace Demeyer and Guy Vundelinckx and N. P. Haas and Ulrich Schaechinger and Laura Wolowicka and Stefan Rammelt and Jan Stroobants and Ingo Marzi and Ansgar M. Brambrink and Piotr Dziurdzik and Jacek G˛asiorowski and Heinz Redl and Michael Beckert and Jasmin Khan-Boluki},
  journal={Critical Care Medicine},
  year={2004},
  volume={32},
  pages={2021-2028}
}
Objective:The objectives of this study were to evaluate safety (primary) and clinical efficacy (secondary) of the humanized monoclonal anti-L-selectin antibody aselizumab in severely injured patients. Design:Prospective phase II, parallel group, double-blind, randomized, placebo-controlled clinical trial. Setting:Fourteen medical intensive care units or trauma units in level I trauma centers in Belgium, Germany, and Poland. Patients:Eighty-four patients with a sustained trauma due to a blunt or… 
The Effect of Anti-L-Selectin (Aselizumab) on the Posttraumatic Inflammatory Response in Multiply Traumatized Patients
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