The effect of anti-D IgG on D-positive recipients.

  title={The effect of anti-D IgG on D-positive recipients.},
  author={B Chown and J. M. Bowman and Janice Pollock and B Lowen and A Pettett},
  journal={Canadian Medical Association journal},
  volume={102 11},
When one standard prophylactic dose of anti-Rh(D) immunoglobulin (Connaught) (and in one case two doses) was injected into 15 D-positive volunteers it caused no reaction and no measurable alteration in readings of hemoglobin, hematocrit, reticulocytes or bilirubin, although some of the volunteers briefly became weakly direct Coombs'-positive. It is argued that since any isohemagglutinin that may contaminate anti-D IgG must be much less in amount than the anti-D it contains, the contaminating… CONTINUE READING