The effect of anosmia on MK-801-induced behaviour in mice

  title={The effect of anosmia on MK-801-induced behaviour in mice},
  author={Peter Andin{\'e} and Rolf Axelsson and Ingemar Jacobson},
  journal={Neuroscience Letters},
Systemic administration of N-methyl-D-aspartate (NMDA) receptor antagonists induces a well defined behaviour in rodents characterized by, for example increased locomotion and ataxia. It is not clear in what brain region(s) NMDA antagonists induce this behaviour. We have studied the possible involvement of olfactory pathways by making adult mice anosmic via intranasal injection of zinc sulphate, a procedure that is known to destroy the olfactory epithelium. The NMDA antagonist MK-801 was given… CONTINUE READING