The effect of anionic amphiphiles on the recruitment of Rac in neutrophils.

@article{Nigorikawa2004TheEO,
  title={The effect of anionic amphiphiles on the recruitment of Rac in neutrophils.},
  author={Kiyomi Nigorikawa and Naoki Okamura and Osamu Hazeki},
  journal={Journal of biochemistry},
  year={2004},
  volume={136 4},
  pages={463-70}
}
Anionic amphiphiles have been shown to influence the NADPH oxidase system. Although one target of the amphiphile action is p47(phox), the cell-free activation of the enzyme in the absence of p47(phox) is also influenced. In the present study, we examined the actions of sodium dodecyl sulfate (SDS) on the NADPH oxidase system in vivo. Treatment of guinea pig neutrophils with the amphiphile caused the translocation of Rac to a membrane fraction and its conversion to the GTP-bound form. Because… CONTINUE READING