The effect of androgen deprivation on malignant and benign prostate tissue.

@article{Guinan1997TheEO,
  title={The effect of androgen deprivation on malignant and benign prostate tissue.},
  author={Patrick Guinan and D Didomenico and John Brown and Melissa Shaw and Rooholiah Sharifi and Vijaylaxmi Ray and Susan B Shott and Marvin Rubenstein},
  journal={Medical oncology},
  year={1997},
  volume={14 3-4},
  pages={145-52}
}
The purpose of this research was to describe the changes in marker expression and histologic morphology following androgen deprivation in malignant and benign human prostates. Fourteen patients receiving pre-radical prostatectomy total androgen deprivation had pre- and post-androgen deprivation evaluation of marker expression and histologic morphology (both malignant and benign). Marker expression was significantly reduced for serum (p < 0.0001) and tissue (p < 0.004) PSA as well as bcl-2… CONTINUE READING