The effect of anabolic–androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area

@article{Roselli1998TheEO,
  title={The effect of anabolic–androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area},
  author={Charles E Roselli},
  journal={Brain Research},
  year={1998},
  volume={792},
  pages={271-276}
}
  • C. Roselli
  • Published 11 May 1998
  • Medicine, Biology
  • Brain Research
Inhibition of Estrogen-Induced Sexual Receptivity by Androgens: Role of the Androgen Receptor
TLDR
Results suggest that naturally occurring and synthetic androgens act at the androgen receptor to inhibit estrogen-induced sexual receptivity in OVX rats.
Increase in [C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids
In the present study, we investigated the alteration of aromatase expression in the brain by anabolic androgenic steroid treatment in male rats. The rats were given nandrolone decanoate (15mg/
Increase in [11C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids
TLDR
The results suggest that aromatase is significantly upregulated in the bed nucleus of the stria terminalis and preoptic area by anabolic androgenic steroids and suggest that androgens regulate aromat enzyme differently in these structures compared with the medial amygdala.
Anabolic Androgenic Steroid Abuse: Multiple Mechanisms of Regulation of GABAergic Synapses in Neuroendocrine Control Regions of the Rodent Forebrain
TLDR
How exposure to AAS alters GABAergic transmission and neural activity within these forebrain regions is reviewed, taking advantage of in vitro systems and both wild‐type and genetically altered mouse strains to better understand how these synthetic steroids affect the neural systems that underlie the regulation of reproduction and the expression of sexual behaviours.
Imaging brain aromatase by using PET : A way to study anabolic steroid abuse
In a previous study, we demonstrated that androgenic-anabolic steroids increased aromatase expression in the bed nucleus of stria terminalis and preoptic area in rat brain, as evaluated using
Alteration in [11C]vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide
TLDR
The findings suggest that aromatase is regulated through an androgen receptor-mediated system and the positron emission tomography technique could be useful for exploring the role of arom atase in anabolic androgenic steroids abusers.
Brain aromatase in control versus castrated Norway Brown, Sprague-Dawley and Wistar adult rats.
TLDR
It is demonstrated that independent of the rat strain examined, MBH/POA aromatase is regulated by androgens (in Sprague-Dawley, Norway Brown and Wistar males).
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It is found that many potent synthetic androgens can bind directly to β protein and to prostate cell nuclei without a metabolic conversion, indicating that the bulkiness and flatness of the steroid molecule play a more important role in receptor binding than the detailed electronic structure at the Δ4 bond of Ring A.
Aromatase activity in the rat brain: Hormonal regulation and sex differences
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  • Medicine, Biology
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Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens
Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.
TLDR
When several anabolic steroids were tested as competitors for the binding of [3H]methyltrienolone (MT; 17 beta-hydroxy-17 alpha-methyl-4,9,11-estratrien-3-one) to the AR in rat and rabbit skeletal muscle and rat prostate, respectively, MT itself was the most efficient competitor.
Anabolic–Androgenic Steroid Effects on the Sexual Behavior of Intact Male Rats
TLDR
In intact male rats the six AAS compounds examined in these studies evoked a range of behavioral and endocrine responses that varied as a function of the specific compound and dose administered.
Androgens regulate aromatase cytochrome P450 messenger ribonucleic acid in rat brain.
TLDR
The results suggest that the increase in AA observed after exposure to androgens results from regulation of the transcription and/or stability of P450AROM mRNA.
Comparison of the effects of stanozolol, oxymetholone, and testosterone cypionate on the sexual behavior of castrated male rats.
TLDR
These 3 AAS compounds produced a range of behavioral and endocrine responses in castrated male rats, with testosterone cypionate sustained ejaculation at all doses tested.
Quantitative distribution of nuclear androgen receptors in microdissected areas of the rat brain.
TLDR
The binding of androgens to specific high-affinity receptor sites in brain tissue is postulated as an initial event in the mechanism of central androgenic action and the first quantitative profile of ARn in discrete brain nuclei and subregions of the rat is provided.
The Role of Aromatization in the Restoration of Male Rat Reproductive Behavior
TLDR
The results lend support to the hypothesis that both androgen receptor activation and aromatization are necessary for the restoration of male sexual behavior in rats and found that estradiol is neither necessary nor sufficient for the restored of partner preference.
Comparison of the effects of 17 alpha-methyltestosterone, methandrostenolone, and nandrolone decanoate on the sexual behavior of castrated male rats.
TLDR
The authors reported that this study is the first to quantify the dose-response characteristics of individual AAS compounds with regard to these behavioral and endocrine measures.
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