The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).

@article{Escolar2014TheEO,
  title={The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).},
  author={Esteban Escolar and Gervasio A. Lamas and Daniel B. Mark and Robin Boineau and C. Goertz and Yves D Rosenberg and Richard L. Nahin and Pamela Ouyang and Theodore C Rozema and Allan Magaziner and Richard Nahas and Eldrin F. Lewis and Lauren Lindblad and Kerry L. Lee},
  journal={Circulation. Cardiovascular quality and outcomes},
  year={2014},
  volume={7 1},
  pages={15-24}
}
BACKGROUND The Trial to Assess Chelation Therapy (TACT) showed clinical benefit of an EDTA-based infusion regimen in patients aged ≥50 years with prior myocardial infarction. Diabetes mellitus before enrollment was a prespecified subgroup. METHODS AND RESULTS Patients received 40 infusions of EDTA chelation or placebo. A total of 633 (37%) patients had diabetes mellitus (322 EDTA and 311 placebo). EDTA reduced the primary end point (death, reinfarction, stroke, coronary revascularization, or… CONTINUE READING

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