The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia.

  title={The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia.},
  author={David Gordon Daniel and Daniel R. Weinberger and Douglas W. Jones and Jeffrey R. Zigun and Raffaella Coppola and Steffen Handel and Llewelyn B Bigelow and Terry E. Goldberg and Karen Faith Berman and Joel Edward Kleinman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={11 7},
To explore the role of monoamines on cerebral function during specific prefrontal cognitive activation, we conducted a double-blind placebo-controlled crossover study of the effects of 0.25 mg/kg oral dextroamphetamine on regional cerebral blood flow (rCBF) as determined by 133Xe dynamic single-photon emission-computed tomography (SPECT) during performance of the Wisconsin Card Sorting Test (WCST) and a sensorimotor control task. Ten patients with chronic schizophrenia who had been stabilized… CONTINUE READING
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