The effect of alternative permutation testing strategies on the performance of multifactor dimensionality reduction


Multifactor Dimensionality Reduction (MDR) is a novel method developed to detect gene-gene interactions in case-control association analysis by exhaustively searching multi-locus combinations. While the end-goal of analysis is hypothesis generation, significance testing is employed to indicate statistical interest in a resulting model. Because the… (More)
DOI: 10.1186/1756-0500-1-139

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