The effect of alternative neuronal differentiation pathways on PC12 cell adhesion and neurite alignment to nanogratings.

@article{Ferrari2010TheEO,
  title={The effect of alternative neuronal differentiation pathways on PC12 cell adhesion and neurite alignment to nanogratings.},
  author={Aldo Ferrari and Paolo Faraci and Marco Cecchini and Fabio Beltram},
  journal={Biomaterials},
  year={2010},
  volume={31 9},
  pages={2565-73}
}
During development and regeneration of the mammalian nervous system, directional signals guide differentiating neurons toward their targets. Soluble neurotrophic molecules encode for preferential direction over long distances while the local topography is read by cells in a process requiring the establishment of focal adhesions. The mutual interaction between overlapping molecular and topographical signals introduces an additional level of control to this picture. The role of the substrate… CONTINUE READING
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Directional PC12 migration along plastic nanotracks

  • A Ferrari, M Cecchini, R Degl’ Innocenti, F. Beltram
  • IEEE Trans Biomed Eng 2009;56:2692–6
  • 2009
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