The effect of alternative neuronal differentiation pathways on PC12 cell adhesion and neurite alignment to nanogratings.


During development and regeneration of the mammalian nervous system, directional signals guide differentiating neurons toward their targets. Soluble neurotrophic molecules encode for preferential direction over long distances while the local topography is read by cells in a process requiring the establishment of focal adhesions. The mutual interaction… (More)
DOI: 10.1016/j.biomaterials.2009.12.010


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