Corpus ID: 5541912

The effect of alpha-tocopherol and beta-tocopherol on proliferation, protein kinase C activity and gene expression in different cell lines.

@article{Fazzio1997TheEO,
  title={The effect of alpha-tocopherol and beta-tocopherol on proliferation, protein kinase C activity and gene expression in different cell lines.},
  author={A. Fazzio and D. Marilley and A. Azzi},
  journal={Biochemistry and molecular biology international},
  year={1997},
  volume={41 1},
  pages={
          93-101
        }
}

A. Fazzio, D. Marilley, A. Azzi

Published 1997

Medicine

Biochemistry and molecular biology international

alpha-Tocopherol, but not beta-tocopherol, negatively regulates proliferation of A7r5 vascular smooth muscle cells at physiological concentration. The HeLa cell line was not affected whereas the Chinese hamster ovary cell line (CHO) was slightly inhibited by both alpha-tocopherol and beta-tocopherol. In A7r5 cells alpha-tocopherol inhibited protein kinase C activity, and this correlated with inhibition of proliferation. beta-Tocopherol did not inhibit either protein kinase C or proliferation… CONTINUE READING

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