Corpus ID: 21268642

The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury.

@article{akr2015TheEO,
  title={The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury.},
  author={T. Çakır and C. Polat and A. Başt{\"u}rk and M. G{\"u}l and A. Aslaner and H. Durgut and A. {\"O}. Şehirli and A. Aykaç and L. Bahar and M. Z. Sabuncuoglu},
  journal={European review for medical and pharmacological sciences},
  year={2015},
  volume={19 11},
  pages={
          2132-9
        }
}
  • T. Çakır, C. Polat, +7 authors M. Z. Sabuncuoglu
  • Published 2015
  • Medicine
  • European review for medical and pharmacological sciences
  • OBJECTIVE The purpose of this study is to determine the antioxidant and anti-inflammatory effects of alpha lipoic acid (ALA) on methotrexate (MTX) induced kidney injury in rats. MATERIALS AND METHODS Thirty-two rats were equally divided into four groups; control, ALA, MTX and MTX with ALA groups. A single dose of MTX (20 mg/kg) was administered to make kidney injury to groups 3 and 4, intraperitoneally. The ALA was administered intraperitonealy in groups 2 and 4 and the other groups received… CONTINUE READING