Corpus ID: 35138023

The effect of alpha-chlorohydrin on the oxidation of fructose by rabbit spermatozoa in vitro.

@article{Ford1983TheEO,
  title={The effect of alpha-chlorohydrin on the oxidation of fructose by rabbit spermatozoa in vitro.},
  author={S. A. Ford and A. Jones},
  journal={Contraception},
  year={1983},
  volume={28 6},
  pages={
          565-73
        }
}
  • S. A. Ford, A. Jones
  • Published 1983
  • Medicine
  • Contraception
  • (R,S)-alpha-Chlorohydrin inhibits the oxidative metabolism of fructose in mature rabbit spermatozoa in vitro. This effect is not noticeable at concentrations of the compound up to 10 mM, is evident at 50 mM but at 100 mM is apparently accompanied by cell damage. At a concentration of 50 mM, (R,S)-alpha-chlorohydrin causes the specific inhibition of the enzyme glyceraldehyde 3-phosphate dehydrogenase and is metabolised by the spermatozoa to 3-chlorolactaldehyde of unknown configuration… CONTINUE READING
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