The effect of alloxan- and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines.

@article{Lopaschuk1983TheEO,
  title={The effect of alloxan- and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines.},
  author={Gary D Lopaschuk and Sidney Katz and John Hugh McNeill},
  journal={Canadian journal of physiology and pharmacology},
  year={1983},
  volume={61 5},
  pages={439-48}
}
Isolated working hearts from diabetic rats have a decreased ability to respond to increasing preload or afterload. The ability of cardiac sarcoplasmic reticulum to transport Ca2+ was examined in diabetic rats. Hearts were obtained from female Wistar rats 120 days or 7 days after the induction of diabetes by a single I.V. injection of either alloxan (65 mg/kg) or streptozotocin (60 mg/kg). At all Ca2+ concentrations tested (0.2-5.0 microM free Ca2+) cardiac sarcoplasmic reticulum from 120-day… CONTINUE READING

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